Can (and has) been done, probably not a good idea, going to be hard work on the truck, and air springs especially under those conditions are going to do their best at putting a single point of pressure on chassis rail directly above axle and more so than they would with properly matched camper to t...

If you really don't need 4 full size seats then a supercab or single cab pickup will mean less chance of having to spend money on suspension changes and will put less stress on the chassis because more of the camper is forward of the rear axle. Have a look at a few pictures of trucks with campers o...